G&A expenses rose to $40.6 million in Q2 2025 from $21.7 million in Q2 2024 due to increased personnel and commercial preparation activities.
Net loss for Q2 2025 was $247.8 million, up from $133.2 million in Q2 2024, mainly due to higher operating expenses.
R&D expenses increased to $224.1 million in Q2 2025 from $134.9 million in Q2 2024, driven by clinical trial and manufacturing costs, primarily for daraxonrasib.
Revolution Medicines ended Q2 2025 with $2.1 billion in cash and investments, including a $250 million royalty monetization tranche from Royalty Pharma.
The Royalty Pharma transaction was accounted for as a liability, with $900,000 noncash interest expense recognized in Q2 2025.
Updated 2025 GAAP net loss guidance is between $1.03 billion and $1.09 billion, reflecting increased expenses from global development and commercialization plans.
Cash generated from operations was approximately $79 million in the quarter, with a strong cash position of over $670 million.
Harmony Biosciences reported second quarter 2025 net revenues of $200.5 million, a 16% increase year-over-year from $172.8 million in Q2 2024.
The company extended its 4-year streak of profitability with non-GAAP adjusted net income of $53.8 million or $0.92 per diluted share, compared to $24.5 million or $0.43 per diluted share in the prior year quarter.
The financial results reflect strong underlying demand for WAKIX, offset by a slight reduction in trade inventories heading into summer months.
Total operating expenses for Q2 2025 were $114.2 million, down from $119.3 million in the same quarter last year.