Adjusted diluted earnings per share (EPS) was $0.78, ahead of expectations, supported by strong top-line performance and cost management.
Adjusted gross margin was approximately 76%, reflecting product mix and expected savings from manufacturing optimization programs.
Adjusted operating expenses declined 8% operationally, with decreases in both selling, general and administrative (SG&A) and research and development (R&D) expenses.
Pfizer reported second quarter 2025 revenues of $14.7 billion, a 10% operational increase driven by growth in both U.S. and international markets.
Recently launched and acquired products generated $4.7 billion in revenue year-to-date, growing approximately 15% operationally versus last year.
Reported diluted EPS was $0.51, benefiting from an efficient operating structure and favorable tax rate changes.
The company returned $4.9 billion to shareholders via dividends in the first half of 2025 and invested $4.7 billion in internal R&D.
Ionis reported revenue of $452 million in Q2 2025, a twofold increase year-over-year, and $584 million for the first six months, up nearly 70% versus prior year.
Non-GAAP net income was $154 million for the quarter.
Operating expenses increased 8% year-over-year, with sales and marketing expenses rising due to Tryngolza launch and Donidalorsen preparations, while R&D expenses decreased as late-stage studies concluded.
R&D collaboration revenue included a $280 million upfront payment for the sapablursen license, nearly 100% of which dropped to the bottom line.
Royalty revenues increased approximately 10% to $70 million, driven by SPINRAZA and Wainua contributions.
Sales and marketing expenses included minority portion of Wainua's sales and marketing costs.
Tryngolza generated $19 million in net product sales in Q2, a threefold increase quarter-over-quarter.
Adjusted EBITDA increased by 59% year-over-year on an underlying basis to $50.8 million.
Adjusted net income grew approximately 85% year-over-year on an underlying basis, reaching $36 million.
Approximately $15 million of common stock was repurchased under the authorized $500 million share repurchase program.
Free cash flow was robust despite a $19.3 million strategic inventory build to support ASCENIV demand, ending the quarter with $90.3 million in cash.
GAAP net income was $34.2 million.
Gross profit rose to $67.2 million with gross margins improving to 55.1%, a 7.7% expansion on an underlying basis.
Total revenues for Q2 2025 reached $122 million, representing a 14% year-over-year increase or approximately 29% growth on an underlying basis excluding a nonrecurring Medicaid rebate accrual reversal from 2024.
Cash and investments totaled $912 million at quarter-end; $560 million in convertible notes due later this year will be retired with cash on hand.
General and administrative expenses rose 17% to $44 million, driven by higher share-based compensation and personnel costs supporting the lung cancer launch and company build-out.
Gross margin was 74%, down from 77% in Q2 2024, mainly due to rollout costs of the HFE array and non-small cell lung cancer launch prior to broad reimbursement.
Net loss was $40 million with a loss per share of $0.36; adjusted EBITDA was negative $10 million.
Net revenues were $159 million, a 6% increase from Q2 2024, driven primarily by 7% active patient growth in the GBM franchise and double-digit growth in international markets.
Research and development expenses were $56 million, up 2% year-over-year, with no expected material step-up this year due to shifting trial spend.
Sales and marketing expenses were $57 million, a 1% increase, reflecting incremental launch costs for non-small cell lung cancer mostly offset by lower stock-based compensation.
The company plans to draw $100 million from its credit facility in September as part of a four-tranche agreement, with the first two tranches obligated to be drawn.
Adjusted EBITDA increased by approximately 33% to $24.8 million, with an adjusted EBITDA margin of 21.9%, a 300 basis point improvement from the prior year.
Artivion reported total constant currency revenue growth of over 14% year-over-year in Q2 2025, reaching $113 million.
Free cash flow was $11.7 million in Q2 2025, with a net leverage ratio reduced to 2.2 from 4.1 in the prior year due to retiring convertible notes.
Gross margins improved slightly to 64.7% (non-GAAP gross margin of 65.1%), driven by favorable mix from AMDS HDE revenues and strong On-X growth.
On-X revenues grew 24%, stent graft revenues grew 22%, BioGlue grew 4%, and tissue processing revenues grew 3% year-over-year on a constant currency basis.
Regional revenue growth was 18% in North America, 15% in Asia Pacific, 10% in EMEA, and 7% in Latin America.
Adjusted EBITDA improved 50% to $4.1 million from $2.6 million in Q2 2024.
Cash and equivalents totaled $72.2 million at quarter-end, with a $25 million drawdown on the credit line in June.
Gross profit margin declined to 72% from 77% due to higher 7D growth and increased international set sales, which have lower margins.
Non-GAAP net loss per share improved to $0.11 from $0.23 in the prior year period.
Operating expenses rose 18% to $54.7 million, driven by $3 million restructuring charges, higher stock compensation, and personnel costs supporting growth.
OrthoPediatrics reported Q2 2025 revenue of $61.1 million, up 16% year-over-year, driven by strong growth in Trauma and Deformity (T&D), Scoliosis, and OPSB segments.
U.S. revenue increased 17% to $48.1 million, representing 79% of total revenue; international revenue grew 12% to $12.9 million.
Cash and equivalents totaled $187.4 million at quarter-end, with cash use down approximately 60% year-over-year.
Net loss was $18.5 million, 46% lower than Q2 2024.
Non-GAAP gross margin expanded by 110 basis points to 38.4%, with product gross margin increasing nearly 400 basis points to 48.9%.
Non-GAAP operating expenses declined 19% to $25.4 million, resulting in a non-GAAP operating loss of $13.4 million, a 36% improvement from the prior year.
Recurring revenue reached $22.5 million, up 11% from Q2 2024, including a 17% increase in consumable revenue.
Revenue for Q2 2025 was $31.4 million, a 15% increase year-over-year, driven by strong Tablo console sales and consistent utilization.