Dafinchi AI

Bristol-Myers Squibb Company

BMY

Healthcare

2w

Strategic Partnership with BioNTech for PD-L1 VEGF Bispecific BNT327

BMS entered into a global strategic partnership with BioNTech to co-develop and commercialize BNT327, a potentially transformative PD-L1 VEGF bispecific therapy.
The collaboration aims to accelerate clinical trials, expedite time to market, and expand indications, with the goal of positioning BNT327 as a first or second to market in its class.
The partnership leverages BMS' expertise in immuno-oncology and BioNTech's innovation, with a focus on speed to market and broadening indications.
Initial clinical development is underway in small cell lung cancer, non-small cell lung cancer, and triple-negative breast cancer.

McKesson Corporation

MCK

Healthcare

1w

McKesson's Strategic Focus on Oncology and Biopharma Expansion

Acquisition of controlling interest in Core Ventures, expanding access to cancer care in local communities.
Growth of U.S. Oncology Network to approximately 3,300 providers across 700 sites in 30 states.
Expansion into other therapeutic areas like ophthalmology with PRISM Vision acquisition.
Leverage of oncology platform to generate data insights and accelerate growth.

Becton, Dickinson and Company

BDX

Healthcare

1w

BD's Strategic Separation of Biosciences and Diagnostics Business

BD announced a definitive agreement to separate its Biosciences and Diagnostics business via a tax-efficient Reverse Morris Trust with Waters, expected to close around the end of Q1 2026.
The separation aims to unlock shareholder value and establish New BD as a pure-play medical technology company with over 90% consumable revenue, a strong innovation pipeline, and margin expansion.
Brooke Story has been appointed to lead the integration and separation management office, leveraging her experience as President of Diagnostics and her role in Edwards Critical Care integration.
The post-separation company is expected to benefit from enhanced capital allocation, including using at least half of the $4 billion cash from Waters for share buybacks, and will maintain a focus on margin expansion and innovation.
The transaction is progressing well, with the expected timeline and strategic benefits clearly articulated, positioning BD for long-term success.

Incyte Corporation

INCY

Healthcare

2w

Strategic Focus on Myeloproliferative Neoplasms (MPNs) as Incyte's Primary Priority

Incyte's leadership emphasizes MPNs as the company's most important therapeutic area, with a potential to transform treatment standards.
The company aims to dominate the MPN space with targeted therapies like 989 and 617, aiming to set a new high watermark in treatment.
Progress with 989 shows promising safety and efficacy, with plans to initiate pivotal trials in ET by early 2026.
The strategic focus on MPNs is driven by the company's asymmetrical advantage and the potential to create a series of innovations in this space.

Bio-Techne Corporation

TECH

Healthcare

1w

Strategic divestiture of Exosome Diagnostics to MDxHealth

Bio-Techne announced the divestiture of Exosome Diagnostics, including the ExoDx prostate test and clinical lab to MDxHealth.
Expected close in the first quarter of fiscal 2026.
Retains access to proprietary exosome technology used in ESR1 mutation kit for breast cancer recurrence.
Repositioning of portfolio to focus on core growth pillars and improve operating margin.

VCYT

Healthcare

1w

Decipher Market Penetration and Growth Drivers

Veracyte delivered approximately 25,500 Decipher tests in Q2, on track to exceed 100,000 tests annually, marking a significant milestone.
Decipher volume grew 28% year-over-year, with 13 consecutive quarters of over 25% growth, driven by strong execution and expanding clinical utility.
The metastatic prostate cancer test launch in June has generated increased physician interest, especially in high-risk NCCN patients, contributing to halo effects and future growth potential.
The company expects Decipher to maintain double-digit growth driven by market share gains, incidence growth, and expanding clinical evidence, including ongoing prospective trials and guideline updates.

Adaptive Biotechnologies Corporation

ADPT

Healthcare

1w

MRD Business Achieves Profitability and Outperforms Expectations

MRD business delivered approximately $2 million in positive adjusted EBITDA, surpassing expectations.
MRD revenue grew 42% year-over-year to $49.9 million, driven by increased clinical volume.
Test volume increased 37% YoY to over 25,300 tests, with multiple myeloma being the largest contributor at 41%.
Blood-based testing now accounts for 44% of MRD tests, up 40% YoY.
The company integrated clonoSEQ into Flatiron's OncoEMR, expanding access in community settings.
Total sequencing gross margin improved by 14 percentage points to 64%.
Cash burn was approximately $11 million, a 36% improvement YoY, with a cash position of $222 million.
Full-year guidance was raised for MRD revenue to $190-$200 million, with expectations of continued volume growth.
The company expects positive adjusted EBITDA to continue into the second half of the year.

AbCellera Biologics Inc.

ABCL

Healthcare

1w

Transition to Clinical-Stage Biotech with First Clinical Trials

AbCellera achieved a major milestone by receiving Health Canada authorization to initiate its first two clinical trials for ABCL635 and ABCL575.
Dosing has begun in the Phase I trial for ABCL635, targeting moderate to severe vasomotor symptoms, marking a shift from platform to clinical-stage biotech.
A second Phase I trial for ABCL575 was also initiated, with dosing expected to start shortly, expanding the company's clinical pipeline.
The company added a third program, ABCL688, into IND-enabling studies, indicating ongoing pipeline expansion and transition into more advanced clinical development.

BioLife Solutions, Inc.

BLFS

Healthcare

1w

Strategic Investment in Pluristyx for Cell Therapy Adjacent Opportunities

BioLife made a strategic investment in Pluristyx, a developer of iPSC-based products, highlighting a focus on adjacent biological assay markets.
The investment aims to explore biological assays as a potential growth area, aligning with BioLife’s core cell processing portfolio.
Pluristyx’s recent launch of an organoid manufacturing assay complements BioLife’s interest in expanding biological applications.
The company views this investment as a disciplined approach to inorganic growth, with potential rights to acquire the target in the future.
Management emphasizes the long-term potential of assays and biological tools to diversify and expand their market presence.

Mersana Therapeutics, Inc.

MRSN

Healthcare

5d

Emi-Le Clinical Data Highlights and Tumor Response Rates

Mersana reported a 31% objective response rate (ORR) in evaluable patients with B7-H4 high tumor expression at ASCO 2025, with doses ranging from 38 to 67 mg/m².
In adenoid cystic carcinoma type 1 (ACC1), 4 confirmed responses and 1 unconfirmed response were observed among 9 evaluable patients, with a confirmed ORR of 56% after data cutoff.
The company emphasized Emi-Le's potential to address unmet needs in triple-negative breast cancer (TNBC) patients previously treated with topoisomerase 1 inhibitors, highlighting poor outcomes with current standard of care.
Data from the TNBC expansion cohort showed a 29% ORR in B7-H4 high patients, with median PFS of 16 weeks, suggesting promising efficacy beyond standard chemotherapy.
Mersana is progressing with dose expansion in TNBC, enrolling over 45 patients across two dosing regimens, with initial data expected in the second half of 2025.
The company believes the post-topo-1 TNBC opportunity is sizable, with Trodelvy expected to generate about $1 billion in 2025, and Emi-Le could serve as a subsequent line of therapy, especially as treatment landscapes evolve.