Agios ended Q2 with approximately $1.3 billion in cash, cash equivalents, and marketable securities.
Cost of sales for the quarter was $1.7 million.
In Q2 2025, Agios reported net revenue of $12.5 million, a 45% increase compared to $8.6 million in Q2 2024 and a 44% increase compared to Q1 2025.
R&D expenses were $91.9 million, up $14.5 million from Q2 2024, primarily due to a $10 million milestone payment to Alnylam related to AG-236 development.
SG&A expenses were $45.9 million, an increase of $10.4 million year-over-year, driven by investments ahead of the potential PYRUKYND thalassemia launch.
The company expects modest full-year 2025 net revenue growth compared to 2024, with quarter-on-quarter variability due to ordering patterns and a sales force transition to thalassemia.
Cash burn for the quarter was approximately $11 million, a 36% improvement over the same period last year, ending with a cash position of $222 million.
ClonoSEQ test volumes increased 37% year-over-year to 25,321 tests delivered.
MRD business achieved positive adjusted EBITDA of $1.9 million, a significant improvement from a $11.3 million deficit a year ago.
MRD business revenue grew 42% year-over-year to $49.9 million, with clinical and pharma contributions of 65% and 35%, respectively.
Net loss for the quarter was $25.6 million.
Sequencing gross margin improved by 14 percentage points year-over-year to 64%.
Total company adjusted EBITDA loss improved to $7.2 million from a $21.4 million loss in the prior year.
Total revenue for Q2 2025 was $58.9 million, a 36% increase year-over-year.
Cash from operations increased by approximately $47 million in the first half of 2025, with a clean balance sheet and strong cash conversion dynamics.
Gross margin improved to 63.4% in Q2 2025 compared to approximately 59% in Q2 2024, with steady sequential margins excluding true-ups despite increased exome volumes.
Natera reported $547 million in revenue for Q2 2025, representing 32% growth year-over-year and 34% growth excluding revenue true-ups.
Non-cash stock-based compensation and legal accruals of about $30 million impacted EPS, with adjusted EPS loss estimated at $0.53 versus reported $0.74.
Operating expenses are expected to remain flat for 2025 despite increased investments, reflecting scale in the business.